Research Training Group 2154 - Materials for Brain

Dr. med. Friedrike Austein

Department of Radiology and Neuroradiology, UKSH, Campus Kiel

Arterial Spin Labeling in Epilepsy

Epileptic foci can present as „hot spots”, i.e. areas of high perfusion in magnetic resonance (MR) perfusion imaging. Foci are most often located in gray matter, an area that is generally highly perfused. The Arterial Spin Labeling (ASL) technique is an MRI method that can visualize perfusion without the application of any external contrast agent. This point is especially advantageous in young children to avoid the application of any external substance as often as possible. As ASL is well suited for gray matter perfusion imaging, this technique can be seen as the optimum for the purpose of visualizing epileptogenic foci. Furthermore, the quantitative post-processing of ASL allows the comparison of results throughout different vendors and field strengths, making it a powerful tool in large cohort studies. We aim to develop special post-processing tools to automatically distinguish epileptogenic foci using ASL perfusion imaging. This approach is based on prior knowledge obtained in clinical routine imaging and validated by experienced radiologists. The data is then post-processed using neuronal networks and compared to a healthy control group, thereby allowing for automatic lesion detection and quantification.