Research Training Group 2154 - Materials for Brain

Project 5: Ankit Mishra

anmi@tf.uni-kiel.de

Responsive materials for drug-release in the brain

Main aim of this project deals with the development of responsive materials for drug delivery in the brain i.e. to achieve the local release of drugs at the site of administration triggered upon the action of stimuli (e.g. light and heat).
Particle based drug delivery systems will be engineered in order to modulate the release of loaded drugs upon action of stimuli. Materials employed for these drug delivery systems will be polymer composites (comprising of metallic nanoparticles), inorganic silica based and hydrogels. Polymers like PLA, PLGA, PCL are extensively used for drug delivery applications due to their outstanding biocompatibility. This project will try to explore these polymers in conjunction with stimuli responsive materials in order to make them photo and temperature responsive.
Inorganic silica based mesoporous nanoparticles exhibit no cytotoxicity, well defined and stabilised structures and most important is the control on pore size in order to efficiently load the guest molecules. Mesoporous networks present on the silica-based particles provides a sustained release kinetics of the loaded cargos. This can be due to the larger surface area and adsorption of molecules over the mesoporous channels. Hence, fabricating a stimuli responsive silica based drug delivery system will offer a very well controlled release profile over a longer period of time.
Hydrogels have higher water content which makes it compatible with biological tissues. Also, presence of hydrophilic groups in hydrogels results into swelling and diffuse out the loaded materials (here it can be drugs), and thus making hydrogels an ideal material for drug delivery applications. Upon action of stimuli such as temperature, pH and light these hydrogels undergo change in volume and makes them to expel out drugs. The fabricated systems will then be studied for controlled release of drugs for treatment of various brain diseases like aneurysms, glioblastoma and epilepsies.

Ankit Mishra