Research Training Group 2154 - Materials for Brain

Project 4: Torge Hartig (Student Representative)

toha@tf.uni-kiel.de

Controlled drug release via stimuli sensitive barrier coatings deposited by initiated chemical vapor deposition

In this project initiated chemical vapor deposition (iCVD) is used to deposit barrier layers to tailor the drug release of an implant. The focus here is on stimuli sensitive barrier layers. For this polymeric barrier layers are deposited, which react for example upon a temperature or magnetic stimulus. This way an externally controllable drug release from an implant can be achieved. By heating above characteristic polymer temperatures, switchable barriers are created that can be applied on their own or in combination with P3. Here either the glass transition temperature or lower critical solution temperature of the polymer coating can nicely be tailored via iCVD, e.g. by changing the degree of crosslinking. 
A further aspect is the tailored deposition of biodegradable barrier layers. For Glioblastoma Multiforme the drug release from an implant should not start earlier than two days after the operation. Here, iCVD is used to create the needed barrier layer. Furthermore, these biodegradable barrier coatings will be used in combination with P1a.
The deposited polymer layers are characterized using different analytical tools, like FTIR, Raman spectroscopy, AFM and XPS to name a few.
The stimuli sensitive barrier coatings are planned to be used for the treatment of epilepsy as well.
 

Hartig