GRK 2154 - Materials for Brain

P11: Hyperpolarized MRI for imaging flow, drugs and metabolism (J. Hövener)

When it comes to chemical analysis or medical diagnosis, MRI and nuclear magnetic resonance (NMR) are powerful and versatile methods. At the same time, both methods are very insensitive: Typically, no more than a few parts per million of a given sample effectively contribute to the MR signal. This fraction, the polarization, is sufficient for imaging water and chemical analysis in vitro. Many other, highly interesting and direly sought-for applications like non-invasive biochemical analysis in vivo are very limited - because of the low polarization and thus sensitivity. This is where hyperpolarization steps in: using dedicated physical “tricks”, the polarization and thus the MR signal can be increased by several orders of magnitude. The goal of this project is to develop a hyperpolarization technology that can be applied to the foci of the RTG 2154: aneurysms, epilepsy and glioblastoma.

 

 Project 11 consists of three work packages:

1. the adaptation of the hyperpolarization technology,

2. the application to vessel imaging,

3, the application for the imaging of drugs.

 

Both imaging of vessels and drugs can benefit strongly from this technology.