GRK 2154 - Materials for Brain

P4: Controlling drug release by barrier layers (F. Faupel)

Together with project P3, this project aims at applying concepts borrowed from microelectronics to release drugs with both, temporal and spatial control. In P4, to control the release of drugs, different types of polymer barrier layers will be used, ranging from hydrophobic fluoropolymers to biodegradable polylactides. These will be deposited directly onto the sample by vapor phase deposition methods. Besides plasma deposition of polymer layers the focus will be mainly on initiated chemical vapor deposition (iCVD), because it allows deposition of polymers with structure and properties very similar to their well known wet chemical counterparts. The deposited polymer layers will be well characterized using different analytical tools, like FTIR, Raman spectroscopy, AFM and XPS to name a few. One important task of the project is the correlation of drug release properties with the polymer barrier properties to finally allow the design of an individual barrier for each desired drug release profile. At a later stage, stimuli sensitive barriers will also be explored for potential in vivo use.