Research Training Group 2154 - Materials for Brain

Project 3: Margarethe Hauck

Microstructured thin-film interpenetrating composites for drug release

Project P3 deals with the development of an implantable drug delivery system (DDS) for the local therapy of brain diseases. Such an implant has to fulfill specific requirements for different disease treatments. This especially includes a suitable size, biocompatibility and appropriate drug release kinetics. Within the 1st generation a micro-channel polydimethylsiloxane (PDMS) matrix was developed which allows for diffusion-controlled sustained drug release. In a next step, a drug reservoir will be introduced into the micro-channel matrix which facilitates a prolonged drug release with zero-order kinetics. In collaboration with P8 and P9, the DDS will be adapted and optimized in vitro and in vivo for the treatment of the brain tumor Glioblastoma multiforme (GBM) (P8) and epilepsy (P9). Especially for the treatment of GBM a delay of the drug release is beneficial. For this, together with project P4, the DDS will be coated with a barrier layer by initiated chemical vapor deposition which dissolves after a certain period of time.