Research Training Group 2154 - Materials for Brain

Prasanth Velvaluri (at University of Minnesota, USA)

Department of Aerospace Engineering Mechanics, Prof. Richard D. James, University of Minnesota, USA (01.08. - 30.09.2019)

Braided Flow Diverter (FD) stents for the treatment of intracranial aneurysms are the current state of the art. However, there is a slight problem with these devices as it was seen clinically that these devices could collapse completely during deployment in certain cases. Therefore, there is a need for the development of new devices to treat aneurysms. Design of such new devices is often the bottleneck in the development process.
During my research stay in the lab of Prof. Dr. Richard James, we worked on exploring the world of origami folding for the design of FD stents. In the course of my time, I worked closely with the members of the group to identify the required designs using group theory. The main condition for a FD stent is that it should have high radial compression (~80%) on folding, so that the stents can fit inside a catheter during deployment. We could identify a couple of designs, which could satisfy these conditions and these were further validated by fabricating a macroscopic model. The first hand results showed that there is a great potential for origami based FD designs for the treatment of aneurysms. I have planned further experiments back in Kiel, to reproduce these designs in microscale for further testing.
Apart from this, I also had a chance to meet many people who work in this area. I also gave an invited talk in the consortium (fluid machinists, physicians and tissue engineers) dedicated for research on aneurysms at the University of Minnesota and in the leading medical device company Medtronic, Minnesota camps. I am quite glad for the opportunity I had during my research stay and I highly recommend such an experience for everyone.

prav Minnesota