Research Training Group 2154 - Materials for Brain

RTG Online Colloquium talk by Prof. Mohsen Akbari: Localized delivery systems for management of glioblastoma

Director Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, BC, Canada

Jul 01, 2020 from 06:00 PM to 07:00 PM

Online

Link to the video-meeting

Meeting-ID: 982 4541 7425
Password: 547379

GlioblastProf. Mohsen Akbarioma (GBM) is the most prevalent and devastating adult primary brain tumor. Current treatment strategies for GBM – including surgery, radiotherapy, and chemotherapy with oral administration of temozolomide (TMZ) – still lead to poor survival rates, leaving the management of GBM a major challenge. Therefore, the development of more effective treatment strategies for GBM is an urgent need. Localized delivery of in a sustained manner using biodegradable polymeric substrates is a promising approach as it allows delivering higher doses of the drugs with a reduced adverse effect on other organs. Additionally, since the drug is delivered directly to the tumor site, the blood-brain-barrier and diffusion-limited drug distribution will no longer be a concern, thus increasing therapeutic choices and allowing for greater personalization of treatments. In this talk, I will summarize our efforts in developing localized delivery systems for the management of GBM. In particular, I will describe the use of smart polymeric microparticles and hydrogel-based drug depots as promising platforms for post-surgical delivery of therapeutics to the tumor site.

 

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