Research Training Group 2154 - Materials for Brain

RTG Online Colloquium talk by Dr. Naomi Larsen: Evaluation of rupture risk and insight into pathogenesis of intracranial aneurysms

Managing Senior Physician, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Campus Kiel

Sep 03, 2020 from 05:00 PM to 06:00 PM

Online

Link to the video-meeting

No password required.

Naomi Larsen

 

 

Background:
Intracranial aneurysms have a prevalence of up to 3 % and generally harbor a low risk of rupture. Still, sub-arachnoid hemorrhage following rupture of an intracranial aneurysm is associated with considerable mortali-ty and morbidity. Therefore, risk stratification of patients diagnosed with an unruptured aneurysm is crucial, but optimal management remains controversial.
Various imaging markers of a higher rupture risk have been described. These include morphologic parame-ters like aneurysm size, ellipticity, or height-width-ratio. Hemodynamic studies have revealed that low flow conditions in the aneurysm sac promote local thrombus formation, inflammatory response and degenerative wall remodeling. Recently, contrast-enhancement of the aneurysm wall on black-blood MRI images (vessel wall imaging) has emerged as a promising surrogate marker. Several studies have investigated the associa-tion of wall enhancement with morphologic and hemodynamic variables, and with histologic findings corre-sponding to inflammation and wall degeneration.

Aim of the project:
The aim of the project lies in the validation of wall enhancement on MR vessel wall imaging as a surrogate marker for a higher risk of rupture in order to implement the method in patient-specific risk stratification and the clinical decision-making process. Furthermore, pathological processes underlying wall enhancement will be investigated to identify new therapeutic approaches.

Methods:
1.    Investigation of pathologic processes in the aneurysm wall and correlation with MR vessel wall im-aging findings
2.    Association of MR vessel wall imaging findings with morphological and hemodynamic risk factors
3.    Correlation of MR vessel wall imaging findings with clinical parameters
4.    Association of MR vessel wall imaging findings with serum biomarkers

 

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