GRK 2154 - Materials for Brain

Ami Kumar

Focus localization and network analysis in children with childhood absence epilepsy

Epilepsy is one of the most common neurological diseases, affecting around 65 million people in the world. It is a disorder in which hyper synchronic activity of the nerve cells in the brain lead to seizures.
This study focuses on comparing and localizing sources and characterizing the patterns of neuronal networks during the course of treatment in children with Childhood Absence Epilepsy (CAE), as well as studying their spatiotemporal frequency network patterns in electroencephalographic (EEG) measurements.
CAE is one of the most common types of Epilepsy found in children, in which the child has staring spells with loss of awareness. Seizure may last for 5-10 seconds and if left untreated they may occur 10- 100 times a day. The age of onset for CAE is 4-10 years with a peak at 5-7 years.

The methods of “dynamic imaging of coherent sources (DICS)” and “renormalized partially directed coherence (RPDC)” will be used. The DICS method determines the neuronal networks and coherence during various brain activities in the frequency domain while the RPDC method exhibits the connectivity and the information flow between coherent sources. Till now the focus of the DICS and RPDC analysis has only been on the most severe clinical stage in patients, but we would like to map the networks through all the stages of epilepsy in a patient using a computational approach. Our aim is to study clinical relevance of networks and dissemination of electrical activities in the brain for therapy and prognosis.